Ion channels are transport proteins present in the lipid bilayers of biological membranes. They are involved in many physiological processes, such as the generation of nerve impulses, hormonal secretion, and heartbeat. Conformational changes in the ion channel-forming protein allow the opening or closing of pores to control the ionic flux through the cell membranes. The opening and closing of the ion channel have been classically treated as a random kinetic process, known as a Markov process. Here the time the channel (...) remains in a given state is assumed to be independent of the condition it had in the previous state. More recently, however, several studies have shown that this process is not random but a deterministic one, where both the open and closed dwell-times and the ionic current flowing through the channel are history-dependent. This property is called long memory or long-range correlation. However, there is still much controversy regarding how this memory originates, which region of the channel is responsible for this property, and which models could best reproduce the memory effect. In this article, we provide a review of what is, where it is, its possible origin, and the mathematical methods used to analyze the long-term memory present in the kinetic process of ion channels. (shrink)

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor (...) evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation. (shrink)

Recently, approach-avoidance tendencies and visual perception biases have been increasingly studied using bistable point-light walkers (PLWs). Prior studies have found a facing-the-viewer bias when one is primed with general threat stimuli (e.g. angry faces), explained by the “error management theory”, as failing to detect a threat as approaching is riskier than the opposite. Importantly, no study has explored how disease threat – linked to the behavioural immune system – might affect this bias. This study aimed to explore whether disease-signalling cues (...) can alter how we perceive the motion direction of ambiguous PLWs. Throughout 3 experiments, participants indicated the motion direction of a bistable PLW previously primed with a control or disease-signalling stimuli – that is, face with a surgical mask (Experiment 1), sickness sound (Experiment 2), or face with a disease cue (Experiment 3). Results showed that sickness cues do not significantly modulate the perception of approach-avoidance behaviours. However, a pattern emerged in Experiments 2 and 3, suggesting that sickness stimuli led to more facing away percepts. Unlike other types of threat, this implies that disease-related threat stimuli might trigger a distinct perceptual bias, indicating a preference to avoid a possible infection source. Nonetheless, this finding warrants future investigations. (shrink)

"From The collected works of C.G. Jung, volumes 4, 8, 12, 16"--P. [i].

This one-volume edition allows the general reader to appreciate Jung's ideas and personality, as they reveal themselves in his comments to his colleagues and to those who approached him with genuine problems of their own, as well as in his communication with personal friends. The correspondence supplies a variety of insights into the genesis of Jung's theories and a running commentary on their development. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available (...) previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

This book is parapsychological study of the meaningful coincidence of events, extrasensory perception, and similar phenomena.

A study of the analogies between alchemy, Christian dogma, and psychological symbolism. Revised translation, with new bibliography and index.

Alchemy is central to Jung's hypothesis of the collective unconscious. In this volume he begins with an outline of the process and aims of psychotherapy, and then moves on to work out the analogies between alchemy, Christian dogma and symbolism and his own understanding of the analytic process. Introducing the basic concepts of alchemy, Jung reminds us of the dual nature of alchemy, comprising both the chemical process and a parallel mystical component. He also discusses the seemingly deliberate mystification of (...) the alchemists. Finally, in using the alchemical process as providing insights into individuation, Jung emphasises the importance of alchemy in relating to us the transcendent nature of the psyche. (shrink)

Reprint. Originally published: 1959; 1st Princeton/Bollingen pbk. ed. published: 1970.

This bibliography records the initial publication of each original work by C.G. Jung, each translation, and significant revisions and expansions of both, up to 1975. In nearly every case, the compilers have examined the publications in German, French and English. Translations are recorded in Danish, Dutch, English, Finnish, French, Greek Hebrew, Hungarian, Italian, Japanese, Norwegian, Portuguese, Russian, Serbo-Croatian, Slovenian, Spanish, Swedish and Turkish. It is arranged according to language, with German and English first, publications being listed chronologically in each language. (...) The _General Bibliography_ lists the contents of the respective volumes of the_ Collected Works_ and the _Gesammelte Werke_, published in Switzerland, and shows the interrelation of the two editions. It also lists Jung's seminars and provides, where possible, information about the origin of works that were first conceived as lectures. An index is provided of all the titles in English and German, and all original works in the other languages. Three specialist indexes, of personal names, organizations and societies and periodicals, complete the work. The publication of the _General Bibliography_, together with the _General Index_, complete the publication of the _Collected Works of C.G. Jung _in English. (shrink)

The purpose of what follows is to show that if we assume March 1, 50 as the date on which ended the five years of imperium given to Caesar by the Lex Licinia Pompeia, we have a hypothesis which ‘works,’ in the sense that, as far as its relevance extends, it enables us to frame a coherent account of the dispute between Caesar and the Senate in the two years preceding the outbreak of civil war. The method followed will be (...) to give a narrative based on that hypothesis and on the evidence which we possess. Many, at least, of the arguments and conclusions here adopted have been put forward already by various writers. I may mention, as an excuse for raising this question again , that a few suggestions will be made which I have not seen elsewhere. For the sake of clearness some very trite matters which belong to the years before 51 will first be recalled. (shrink)

In this book, C. G. Prado addresses the difficult question of when and whether it is rational to end one's life in order to escape devastating terminal illness. He specifically considers this question in light of the impact of multiculturalism on perceptions and judgements about what is right and wrong, permissible and impermissible. Prado introduces the idea of a 'coincidental culture' to clarify the variety of values and commitments that influence decision. He also introduces the idea of a 'proxy premise' (...) to deal with reasoning issues that are raised by intractably held beliefs. Primarily intended for medical ethicists, this book will be of interest to anyone concerned about the ability of modern medicine to keep people alive, thereby forcing people to choose between living and dying. In addition, Prado calls upon medical ethicists and practitioners to appreciate the value of a theoretical basis for their work. (shrink)

Contents: Mandalas. I. A Study in the Process of Individuation. II. Concerning Mandala Symbolism Index Originally published in 1972. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in (...) the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

This book examines the reactions of the friends and family of those who elect to die due to terminal illness. These surviving spouses, partners, relatives, and friends, in addition to coping with the death of a loved one, must also deal with the loved one's decision to die, thus severing the relationship. C. G. Prado examines how reactions to elective death are influenced by cultural influences and beliefs, particularly those related to life, death, and the possibility of an afterlife. Understanding (...) the role of these cultural influences on the grieving processes of survivors is a crucial step in allowing them to accept both intellectually and emotionally the finality of elective death and to deal with the decision of their loved one. (shrink)

Book Information Truth and Truthfulness: An Essay in Genealogy. Truth and Truthfulness: An Essay in Genealogy Bernard Williams , Princeton : Princeton University Press , 2002 , 328 , US$27.95 ( cloth ) By Bernard Williams. Princeton University Press. Princeton. Pp. 328. US$27.95 (cloth:).

Concern with elective-death decisions usually focuses on individuals' competence and understanding of their situations and prospects. If problematic influences on individuals are considered, they almost invariably have to do with matters such as depression and the effects of medication. Too little attention is paid to how individuals, as subjects, are products of both external cultural and social influences on them, and of internal efforts and needs that determine their subjectivity.

This volume from the _Collected Works of C.G. Jung_ has become known as perhaps the best introduction to Jung's work. In these famous essays he presented the essential core of his system. This is the first paperback publication of this key work in its revised and augmented second edition. The earliest versions of the essays are included in an Appendices, containing as they do the first tentative formulations of Jung's concept of archetypes and the collective unconscious, as well as his (...) germinating theory of types. (shrink)

Recently, Brukner and Zeilinger (Phys. Rev. Lett. 83(17) (2001) 3354) have claimed that the Shannon information is not well defined as a measure of information in quantum mechanics, adducing arguments that seek to show that it is inextricably tied to classical notions of measurement. It is shown here that these arguments do not succeed: the Shannon information does not have problematic ties to classical concepts. In a further argument, Brukner and Zeilinger compare the Shannon information unfavourably to their preferred information (...) measure, I(p), with regard to the definition of a notion of ''total information content.'' This argument is found unconvincing and the relationship between individual measures of information and notions of ''total information content'' investigated. We close by considering the prospects of Zeilinger's Foundational Principle as a foundational principle for quantum mechanics. (shrink)

_Psychological Types_ is one of Jung's most important and most famous works. First published by Routledge in the early 1920s it appeared after Jung's so-called fallow period, during which he published little, and it is perhaps the first significant book to appear after his own confrontation with the unconscious. It is the book that introduced the world to the terms 'extravert' and 'introvert'. Though very much associated with the unconscious, in _Psychological Types_ Jung shows himself to be a supreme theorist (...) of the conscious. In putting forward his system of psychological types Jung provides a means for understanding ourselves and the world around us: our different patterns of behaviour, our relationships, marriage, national and international conflict, organizational functioning. Appearing in paperback for the first time this central volume from Jung's Collected Works will be essential to anyone requiring a proper understanding of Jung's psychology. (shrink)

I HAVE to correct a mistake in my article in the last number of the C.Q., on p. 195, n. 1. The sentence containing it runs; ‘Thus, for the consular provinces of 51–50, the Senate picked out the two senior ex-consuls who had not yet held consular governorships.’ But, to begin with, it is apparent from Caesar, B.C. I. 6, 5, that Cotta, who had been consul in 65, and was therefore senior to Cicero and Bibulus, had not held a (...) consular province by 49. And secondly, as to what was done in determining who should have the consular provinces of 51–50, there seems to be no evidence. Cicero's statement in Ad Fam. III. 2, i, that praeter opinionem it had become necessary for him to go out to a province, may mean that he had counted on being unaffected by the regulations of 52, and that either a subsequent decree of the Senate or some arrangement made by a few senatorial leaders had upset his expectations. But of course praeter opinionem may refer to his not having expected before 52 that he would have to undertake a governorship. Nor can we tell whether his words, Vides ex senatus consulto provinciam esse habendam, refer to a decree prescribing who should draw lots for the consular provinces of 51–50, or merely to a decree which had the effect of obliging Appius to hand over Cilicia to a successor. However, the point that after 52 the Senate or its leaders had some power to determine what ex-magistrates should draw lots for provinces, seems to be sufficiently proved by Ad Fam. VIII. 8, 8, where praetorian provinces are concerned, and Caesar, B.C. I. 85, 9. (shrink)